Structure-guided glyco-engineering of ACE2 for improved potency as soluble SARS-CoV-2 decoy receptor

Infection and viral entry of SARS-CoV-2 crucially depends on the binding of its Spike protein to angiotensin converting enzyme 2 (ACE2) presented on host cells. Glycosylation of both proteins is critical for this interaction. Recombinant soluble human ACE2 can neutralize SARS-CoV-2 and is currently...

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Detalles Bibliográficos
Autores principales: Capraz, Tümay, Kienzl, Nikolaus F, Laurent, Elisabeth, Perthold, Jan W, Föderl-Höbenreich, Esther, Grünwald-Gruber, Clemens, Maresch, Daniel, Monteil, Vanessa, Niederhöfer, Janine, Wirnsberger, Gerald, Mirazimi, Ali, Zatloukal, Kurt, Mach, Lukas, Penninger, Josef M, Oostenbrink, Chris, Stadlmann, Johannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8730730/
https://www.ncbi.nlm.nih.gov/pubmed/34927585
http://dx.doi.org/10.7554/eLife.73641

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8730730/
https://www.ncbi.nlm.nih.gov/pubmed/34927585
http://dx.doi.org/10.7554/eLife.73641

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