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Antibody secreting cells are critically dependent on integrin α4β7/MAdCAM-1 for intestinal recruitment and control of the microbiota during chronic colitis
T and B cells employ integrin α4β7 to migrate to intestine under homeostatic conditions. Whether those cells differentially rely on α4β7 for homing during inflammatory conditions has not been fully examined. This may have implications for our understanding of the mode of action of anti-integrin ther...
Autores principales: | Tyler, Christopher J., Guzman, Mauricio, Lundborg, Luke R., Yeasmin, Shaila, Zgajnar, Nadia, Jedlicka, Paul, Bamias, Giorgos, Rivera-Nieves, Jesús |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group US
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8732264/ https://www.ncbi.nlm.nih.gov/pubmed/34433904 http://dx.doi.org/10.1038/s41385-021-00445-z |
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