3-Ketodihydrosphingosine reductase maintains ER homeostasis and unfolded protein response in leukemia

Sphingolipids and their metabolic pathways have been implicated in disease development and therapeutic response; however, the detailed mechanisms remain unclear. Using a sphingolipid network focused CRISPR/Cas9 library screen, we identified an endoplasmic reticulum (ER) enzyme, 3-Ketodihydrosphingos...

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Detalles Bibliográficos
Autores principales: Liu, Qiao, Chan, Anthony K.N., Chang, Wen-Han, Yang, Lu, Pokharel, Sheela Pangeni, Miyashita, Kazuya, Mattson, Nicole, Xu, Xiaobao, Li, Mingli, Lu, Wei, Lin, Ren-Jang, Wang, Shao-Yuan, Chen, Chun-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8732298/
https://www.ncbi.nlm.nih.gov/pubmed/34373586
http://dx.doi.org/10.1038/s41375-021-01378-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8732298/
https://www.ncbi.nlm.nih.gov/pubmed/34373586
http://dx.doi.org/10.1038/s41375-021-01378-z

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