Identification of structurally diverse menaquinone-binding antibiotics with in vivo activity against multidrug-resistant pathogens

The emergence of multidrug-resistant bacteria poses a threat to global health and necessitates the development of additional in vivo active antibiotics with diverse modes of action (MOA). Directly targeting menaquinone (MK), which plays an important role in bacterial electron transport, is an appeal...

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Detalles Bibliográficos
Autores principales: Li, Lei, Koirala, Bimal, Hernandez, Yozen, MacIntyre, Logan W., Ternei, Melinda A., Russo, Riccardo, Brady, Sean F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8732328/
https://www.ncbi.nlm.nih.gov/pubmed/34949828
http://dx.doi.org/10.1038/s41564-021-01013-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8732328/
https://www.ncbi.nlm.nih.gov/pubmed/34949828
http://dx.doi.org/10.1038/s41564-021-01013-8

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