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Identification of structurally diverse menaquinone-binding antibiotics with in vivo activity against multidrug-resistant pathogens
The emergence of multidrug-resistant bacteria poses a threat to global health and necessitates the development of additional in vivo active antibiotics with diverse modes of action (MOA). Directly targeting menaquinone (MK), which plays an important role in bacterial electron transport, is an appeal...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8732328/ https://www.ncbi.nlm.nih.gov/pubmed/34949828 http://dx.doi.org/10.1038/s41564-021-01013-8 |