IL-6 and TNFα Drive Extensive Proliferation of Human Tregs Without Compromising Their Lineage Stability or Function

Treg therapies are being tested in clinical trials in transplantation and autoimmune diseases, however, the impact of inflammation on Tregs remains controversial. We challenged human Tregs ex-vivo with pro-inflammatory cytokines IL-6 and TNFα and observed greatly enhanced proliferation stimulated by...

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Detalles Bibliográficos
Autores principales: Skartsis, Nikolaos, Peng, Yani, Ferreira, Leonardo M. R., Nguyen, Vinh, Ronin, Emilie, Muller, Yannick D., Vincenti, Flavio, Tang, Qizhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8732758/
https://www.ncbi.nlm.nih.gov/pubmed/35003100
http://dx.doi.org/10.3389/fimmu.2021.783282

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8732758/
https://www.ncbi.nlm.nih.gov/pubmed/35003100
http://dx.doi.org/10.3389/fimmu.2021.783282

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