SAHA could inhibit TGF-β1/p38 pathway in MI-induced cardiac fibrosis through DUSP4 overexpression

Growing evidences have revealed that a histone deacetylase inhibitor (HDACi), suberoylanilide hydroxamic acid (SAHA) has anti-fibrotic effect in different diseases. In this study, we first evaluated whether SAHA could suppress cardiac fibrosis. Mice with MI-induced cardiac fibrosis were treated with...

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Detalles Bibliográficos
Autores principales: Wang, Kaihao, Tang, Ruijie, Wang, Siyuan, Wang, Wenyao, Zhang, Kuo, Li, Jun, Li, Ping, Tang, Yi-Da
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Japan 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8732849/
https://www.ncbi.nlm.nih.gov/pubmed/34236463
http://dx.doi.org/10.1007/s00380-021-01900-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8732849/
https://www.ncbi.nlm.nih.gov/pubmed/34236463
http://dx.doi.org/10.1007/s00380-021-01900-4

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