PPARα−ACOT12 axis is responsible for maintaining cartilage homeostasis through modulating de novo lipogenesis

Here, in Ppara(−/−) mice, we found that an increased DNL stimulated the cartilage degradation and identified ACOT12 as a key regulatory factor. Suppressed level of ACOT12 was observed in cartilages of OA patient and OA-induced animal. To determine the role and association of ACOT12 in the OA pathoge...

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Detalles Bibliográficos
Autores principales: Park, Sujeong, Baek, In-Jeoung, Ryu, Ji Hyun, Chun, Churl-Hong, Jin, Eun-Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8733009/
https://www.ncbi.nlm.nih.gov/pubmed/34987154
http://dx.doi.org/10.1038/s41467-021-27738-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8733009/
https://www.ncbi.nlm.nih.gov/pubmed/34987154
http://dx.doi.org/10.1038/s41467-021-27738-y

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