South Asian-Specific MYBPC3(Δ25bp) Deletion Carriers Display Hypercontraction and Impaired Diastolic Function Under Exercise Stress

Background: A 25-base pair (25bp) intronic deletion in the MYBPC3 gene enriched in South Asians (SAs) is a risk allele for late-onset left ventricular (LV) dysfunction, hypertrophy, and heart failure (HF) with several forms of cardiomyopathy. However, the effect of this variant on exercise parameter...

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Detalles Bibliográficos
Autores principales: Bazrafshan, Sholeh, Sibilia, Robert, Girgla, Saavia, Viswanathan, Shiv Kumar, Puckelwartz, Megan J., Sangha, Kiranpal S., Singh, Rohit R., Kakroo, Mashhood, Jandarov, Roman, Harris, David M., Rubinstein, Jack, Becker, Richard C., McNally, Elizabeth M., Sadayappan, Sakthivel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8733148/
https://www.ncbi.nlm.nih.gov/pubmed/35004883
http://dx.doi.org/10.3389/fcvm.2021.766339

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8733148/
https://www.ncbi.nlm.nih.gov/pubmed/35004883
http://dx.doi.org/10.3389/fcvm.2021.766339

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