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South Asian-Specific MYBPC3(Δ25bp) Deletion Carriers Display Hypercontraction and Impaired Diastolic Function Under Exercise Stress

Background: A 25-base pair (25bp) intronic deletion in the MYBPC3 gene enriched in South Asians (SAs) is a risk allele for late-onset left ventricular (LV) dysfunction, hypertrophy, and heart failure (HF) with several forms of cardiomyopathy. However, the effect of this variant on exercise parameter...

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Detalles Bibliográficos
Autores principales:	Bazrafshan, Sholeh, Sibilia, Robert, Girgla, Saavia, Viswanathan, Shiv Kumar, Puckelwartz, Megan J., Sangha, Kiranpal S., Singh, Rohit R., Kakroo, Mashhood, Jandarov, Roman, Harris, David M., Rubinstein, Jack, Becker, Richard C., McNally, Elizabeth M., Sadayappan, Sakthivel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cardiovascular Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8733148/ https://www.ncbi.nlm.nih.gov/pubmed/35004883 http://dx.doi.org/10.3389/fcvm.2021.766339

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