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Proteinopathies as Hallmarks of Impaired Gene Expression, Proteostasis and Mitochondrial Function in Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a fatal adult-onset neurodegenerative disease characterized by progressive degeneration of upper and lower motor neurons. As with the majority of neurodegenerative diseases, the pathological hallmarks of ALS involve proteinopathies which lead to the formation o...
Autores principales: | Benson, Bridget C., Shaw, Pamela J., Azzouz, Mimoun, Highley, J. Robin, Hautbergue, Guillaume M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8733206/ https://www.ncbi.nlm.nih.gov/pubmed/35002606 http://dx.doi.org/10.3389/fnins.2021.783624 |
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