Discovery of small-molecule positive allosteric modulators of Parkin E3 ligase

Pharmacological activation of the E3 ligase Parkin represents a rational therapeutic intervention for the treatment of Parkinson’s disease. Here we identify several compounds that enhance the activity of wildtype Parkin in the presence of phospho-ubiquitin and act as positive allosteric modulators (...

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Detalles Bibliográficos
Autores principales: Shlevkov, Evgeny, Murugan, Paramasivam, Montagna, Dan, Stefan, Eric, Hadzipasic, Adelajda, Harvey, James S., Kumar, P. Rajesh, Entova, Sonya, Bansal, Nupur, Bickford, Shari, Wong, Lai-Yee, Hirst, Warren D., Weihofen, Andreas, Silvian, Laura F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8733272/
https://www.ncbi.nlm.nih.gov/pubmed/35024585
http://dx.doi.org/10.1016/j.isci.2021.103650

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8733272/
https://www.ncbi.nlm.nih.gov/pubmed/35024585
http://dx.doi.org/10.1016/j.isci.2021.103650

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