A Deletion of the Nuclear Localization Signal Domain in the Fus Protein Induces Stable Post-stress Cytoplasmic Inclusions in SH-SY5Y Cells

Mutations in Fused-in-Sarcoma (FUS) gene involving the nuclear localization signal (NLS) domain lead to juvenile-onset Amyotrophic Lateral Sclerosis (ALS). The mutant protein mislocalizes to the cytoplasm, incorporating it into Stress Granules (SG). Whether SGs are the first step to the formation of...

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Detalles Bibliográficos
Autores principales: Notaro, Antonietta, Messina, Antonella, La Bella, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8733393/
https://www.ncbi.nlm.nih.gov/pubmed/35002600
http://dx.doi.org/10.3389/fnins.2021.759659

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8733393/
https://www.ncbi.nlm.nih.gov/pubmed/35002600
http://dx.doi.org/10.3389/fnins.2021.759659

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