Nano-Delivery of a Novel Inhibitor of Polynucleotide Kinase/Phosphatase (PNKP) for Targeted Sensitization of Colorectal Cancer to Radiation-Induced DNA Damage

Inhibition of the DNA repair enzyme polynucleotide kinase/phosphatase (PNKP) increases the sensitivity of cancer cells to DNA damage by ionizing radiation (IR). We have developed a novel inhibitor of PNKP, i.e., A83B4C63, as a potential radio-sensitizer for the treatment of solid tumors. Systemic de...

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Detalles Bibliográficos
Autores principales: Sadat, Sams M. A., Wuest, Melinda, Paiva, Igor M., Munira, Sirazum, Sarrami, Nasim, Sanaee, Forughalsadat, Yang, Xiaoyan, Paladino, Marco, Binkhathlan, Ziyad, Karimi-Busheri, Feridoun, Martin, Gary R., Jirik, Frank R., Murray, David, Gamper, Armin M., Hall, Dennis G., Weinfeld, Michael, Lavasanifar, Afsaneh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8733593/
https://www.ncbi.nlm.nih.gov/pubmed/35004293
http://dx.doi.org/10.3389/fonc.2021.772920

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8733593/
https://www.ncbi.nlm.nih.gov/pubmed/35004293
http://dx.doi.org/10.3389/fonc.2021.772920

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