Cargando…

Nano-Delivery of a Novel Inhibitor of Polynucleotide Kinase/Phosphatase (PNKP) for Targeted Sensitization of Colorectal Cancer to Radiation-Induced DNA Damage

Inhibition of the DNA repair enzyme polynucleotide kinase/phosphatase (PNKP) increases the sensitivity of cancer cells to DNA damage by ionizing radiation (IR). We have developed a novel inhibitor of PNKP, i.e., A83B4C63, as a potential radio-sensitizer for the treatment of solid tumors. Systemic de...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sadat, Sams M. A., Wuest, Melinda, Paiva, Igor M., Munira, Sirazum, Sarrami, Nasim, Sanaee, Forughalsadat, Yang, Xiaoyan, Paladino, Marco, Binkhathlan, Ziyad, Karimi-Busheri, Feridoun, Martin, Gary R., Jirik, Frank R., Murray, David, Gamper, Armin M., Hall, Dennis G., Weinfeld, Michael, Lavasanifar, Afsaneh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8733593/ https://www.ncbi.nlm.nih.gov/pubmed/35004293 http://dx.doi.org/10.3389/fonc.2021.772920

Ejemplares similares

Biodistribution and Activity of EGFR Targeted Polymeric Micelles Delivering a New Inhibitor of DNA Repair to Orthotopic Colorectal Cancer Xenografts with Metastasis
por: de Paiva, Igor Moura, et al.
Publicado: (2022)

Independent mechanisms of stimulation of polynucleotide kinase/phosphatase by phosphorylated and non-phosphorylated XRCC1
por: Lu, Meiling, et al.
Publicado: (2010)

Development of Self-Associating SN-38-Conjugated Poly(ethylene oxide)-Poly(ester) Micelles for Colorectal Cancer Therapy
por: Sadat, Sams M. A., et al.
Publicado: (2020)

The Rev1 interacting region (RIR) motif in the scaffold protein XRCC1 mediates a low-affinity interaction with polynucleotide kinase/phosphatase (PNKP) during DNA single-strand break repair
por: Breslin, Claire, et al.
Publicado: (2017)

PNKP is required for maintaining the integrity of progenitor cell populations in adult mice
por: Shin, Wisoo, et al.
Publicado: (2021)

Site-specific acetylation of polynucleotide kinase 3’-phosphatase (PNKP) regulates its distinct role in DNA repair pathways
por: Islam, Azharul, et al.
Publicado: (2023)

Mitigation of Tacrolimus-Associated Nephrotoxicity by PLGA Nanoparticulate Delivery Following Multiple Dosing to Mice while Maintaining its Immunosuppressive Activity
por: Alshamsan, Aws, et al.
Publicado: (2020)

Role of polynucleotide kinase/phosphatase in mitochondrial DNA repair
por: Tahbaz, Nasser, et al.
Publicado: (2012)

Design and Development of D‒α‒Tocopheryl Polyethylene Glycol Succinate‒block‒Poly(ε-Caprolactone) (TPGS−b−PCL) Nanocarriers for Solubilization and Controlled Release of Paclitaxel
por: Yusuf, Osman, et al.
Publicado: (2021)

The polynucleotide kinase 3′-phosphatase gene (PNKP) is involved in Charcot-Marie-Tooth disease (CMT2B2) previously related to MED25
por: Leal, Alejandro, et al.
Publicado: (2018)

Senescence evasion by MCF-7 human breast tumor-initiating cells
por: Karimi-Busheri, Feridoun, et al.
Publicado: (2010)

Zika Virus Induces Mitotic Catastrophe in Human Neural Progenitors by Triggering Unscheduled Mitotic Entry in the Presence of DNA Damage While Functionally Depleting Nuclear PNKP
por: Rychlowska, Malgorzata, et al.
Publicado: (2022)

Mechanism of DNA substrate recognition by the mammalian DNA repair enzyme, Polynucleotide Kinase
por: Bernstein, N. K., et al.
Publicado: (2009)

Mutational survivorship bias: The case of PNKP
por: Bermúdez-Guzmán, Luis, et al.
Publicado: (2020)

Structural and functional characterization of the PNKP–XRCC4–LigIV DNA repair complex
por: Aceytuno, R. Daniel, et al.
Publicado: (2017)

Decoration of Anti-CD38 on Nanoparticles Carrying a STAT3 Inhibitor Can Improve the Therapeutic Efficacy Against Myeloma
por: Huang, Yung-Hsing, et al.
Publicado: (2019)

Mutations in PNKP cause microcephaly, seizures and defects in DNA repair
por: Shen, Jun, et al.
Publicado: (2010)

Mutation in PNKP presenting initially as axonal Charcot-Marie-Tooth disease
por: Pedroso, José Luiz, et al.
Publicado: (2015)

Enzymes of Polynucleotide Metabolism
por: King, Mary E.
Publicado: (1960)

Double-Stranded Polynucleotides as Interferon Inducers
por: Field, A. K., et al.
Publicado: (1970)

Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription
por: Gao, Rui, et al.
Publicado: (2019)

Mutations in PNKP Cause Recessive Ataxia with Oculomotor Apraxia Type 4
por: Bras, Jose, et al.
Publicado: (2015)

Mutations of the DNA repair gene PNKP in a patient with microcephaly, seizures, and developmental delay (MCSZ) presenting with a high-grade brain tumor
por: Jiang, Bingcheng, et al.
Publicado: (2022)

Nanoparticulate systems for polynucleotide delivery
por: Basarkar, Ashwin, et al.
Publicado: (2007)

Phosphorylation of PNKP by ATM prevents its proteasomal degradation and enhances resistance to oxidative stress
por: Parsons, Jason L., et al.
Publicado: (2012)

Achievements and Challenges in Transplantation of Mesenchymal Stem Cells in Otorhinolaryngology
por: Kaboodkhani, Reza, et al.
Publicado: (2021)

Development and characterization of methoxy poly(ethylene oxide)-block-poly(ε-caprolactone) (PEO-b-PCL) micelles as vehicles for the solubilization and delivery of tacrolimus
por: Ali, Raisuddin, et al.
Publicado: (2017)

Structure and mechanism of Mycobacterium smegmatis polynucleotide phosphorylase
por: Unciuleac, Mihaela-Carmen, et al.
Publicado: (2021)

Molecular integrity and global gene expression of breast and lung cancer stem cells under long-term storage and recovery
por: Karimi-Busheri, Feridoun, et al.
Publicado: (2012)

Therapeutic Effect of Mesenchymal Stem Cells in Ulcerative Colitis: A Review on Achievements and Challenges
por: Hosseini-Asl, Seyed-Kazem, et al.
Publicado: (2020)

Study on Interaction of Cationic Porphyrazine with Synthetic Polynucleotides
por: Dezhampanah, Hamid, et al.
Publicado: (2013)

Novel Aspects of Polynucleotide Phosphorylase Function in Streptomyces
por: Jones, George H.
Publicado: (2018)

Conformation-dependent restraints for polynucleotides: the sugar moiety
por: Kowiel, Marcin, et al.
Publicado: (2020)

Reconstitution and structure of a bacterial Pnkp1–Rnl–Hen1 RNA repair complex
por: Wang, Pei, et al.
Publicado: (2015)

PNKP Mutations Identified by Whole-Exome Sequencing in a Norwegian Patient with Sporadic Ataxia and Edema
por: Tzoulis, C., et al.
Publicado: (2016)

Shedding Light on the Elephant in a Dark Room in the Discovery of New Medicine: Highlighting Molecular Pharmaceutics within ACS Bio & Med Chem Au
por: Lavasanifar, Afsaneh, et al.
Publicado: (2022)

Complexation of Oligo- and Polynucleotides with Methoxyphenyl-Functionalized Imidazolium Surfactants
por: Kuznetsova, Darya A., et al.
Publicado: (2022)

Polynucleotide phosphorylase has an impact on cell biology of Campylobacter jejuni
por: Haddad, Nabila, et al.
Publicado: (2012)

CD24(+)/CD38(-) as new prognostic marker for non-small cell lung cancer
por: Karimi-Busheri, Feridoun, et al.
Publicado: (2013)

Morphological and molecular characteristics of spheroid formation in HT-29 and Caco-2 colorectal cancer cell lines
por: Gheytanchi, Elmira, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ol0te0lonubg039pidrk99lptq