Exendin-4 Preserves Blood-Brain Barrier Integrity via Glucagon-Like Peptide 1 Receptor/Activated Protein Kinase-Dependent Nuclear Factor-Kappa B/Matrix Metalloproteinase-9 Inhibition After Subarachnoid Hemorrhage in Rat

In this study, we investigated the role of Exendin-4 (Ex-4), a glucagon-like peptide 1 receptor (GLP-1R) agonist, in blood-brain barrier (BBB) disruption after subarachnoid hemorrhage (SAH) in rats. The endovascular perforation model of SAH was performed in Sprague-Dawley rats. Ex-4 was intraperiton...

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Detalles Bibliográficos
Autores principales: Xie, Zhiyi, Enkhjargal, Budbazar, Nathanael, Matei, Wu, Lingyun, Zhu, Qiquan, Zhang, Tongyu, Tang, Jiping, Zhang, John H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8733623/
https://www.ncbi.nlm.nih.gov/pubmed/35002615
http://dx.doi.org/10.3389/fnmol.2021.750726

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8733623/
https://www.ncbi.nlm.nih.gov/pubmed/35002615
http://dx.doi.org/10.3389/fnmol.2021.750726

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