Physiologically Based Pharmacokinetic Modeling of Cefadroxil in Mouse, Rat, and Human to Predict Concentration–Time Profile at Infected Tissue

The aim of this study was to develop physiologically based pharmacokinetic (PBPK) models capable of simulating cefadroxil concentrations in plasma and tissues in mouse, rat, and human. PBPK models in this study consisted of 14 tissues and 2 blood compartments. They were established using measured ti...

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Detalles Bibliográficos
Autores principales: Tan, Zhongxia, Zhang, Youxi, Wang, Chao, Sun, Le
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8733657/
https://www.ncbi.nlm.nih.gov/pubmed/35002687
http://dx.doi.org/10.3389/fphar.2021.692741

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8733657/
https://www.ncbi.nlm.nih.gov/pubmed/35002687
http://dx.doi.org/10.3389/fphar.2021.692741

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