scDALI: modeling allelic heterogeneity in single cells reveals context-specific genetic regulation

While it is established that the functional impact of genetic variation can vary across cell types and states, capturing this diversity remains challenging. Current studies using bulk sequencing either ignore this heterogeneity or use sorted cell populations, reducing discovery and explanatory power...

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Detalles Bibliográficos
Autores principales: Heinen, Tobias, Secchia, Stefano, Reddington, James P., Zhao, Bingqing, Furlong, Eileen E. M., Stegle, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8734213/
https://www.ncbi.nlm.nih.gov/pubmed/34991671
http://dx.doi.org/10.1186/s13059-021-02593-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8734213/
https://www.ncbi.nlm.nih.gov/pubmed/34991671
http://dx.doi.org/10.1186/s13059-021-02593-8

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