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scDALI: modeling allelic heterogeneity in single cells reveals context-specific genetic regulation
While it is established that the functional impact of genetic variation can vary across cell types and states, capturing this diversity remains challenging. Current studies using bulk sequencing either ignore this heterogeneity or use sorted cell populations, reducing discovery and explanatory power...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8734213/ https://www.ncbi.nlm.nih.gov/pubmed/34991671 http://dx.doi.org/10.1186/s13059-021-02593-8 |