Improving dexamethasone drug loading and efficacy in treating arthritis through a lipophilic prodrug entrapped into PLGA-PEG nanoparticles

Targeted delivery of dexamethasone to inflamed tissues using nanoparticles is much-needed to improve its efficacy while reducing side effects. To drastically improve dexamethasone loading and prevent burst release once injected intravenously, a lipophilic prodrug dexamethasone palmitate (DXP) was en...

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Detalles Bibliográficos
Autores principales: Simón-Vázquez, Rosana, Tsapis, Nicolas, Lorscheider, Mathilde, Rodríguez, Ainhoa, Calleja, Patricia, Mousnier, Ludivine, de Miguel Villegas, Encarnación, González-Fernández, África, Fattal, Elias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8734546/
https://www.ncbi.nlm.nih.gov/pubmed/34993924
http://dx.doi.org/10.1007/s13346-021-01112-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8734546/
https://www.ncbi.nlm.nih.gov/pubmed/34993924
http://dx.doi.org/10.1007/s13346-021-01112-3

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