Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism

The Tricarboxylic Acid (TCA) Cycle is arguably the most critical metabolic cycle in physiology and exists as an essential interface coordinating cellular metabolism, bioenergetics, and redox homeostasis. Despite decades of research, a comprehensive investigation into the consequences of TCA cycle dy...

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Detalles Bibliográficos
Autores principales: Ryan, Dylan Gerard, Yang, Ming, Prag, Hiran A, Blanco, Giovanny Rodriguez, Nikitopoulou, Efterpi, Segarra-Mondejar, Marc, Powell, Christopher A, Young, Tim, Burger, Nils, Miljkovic, Jan Lj, Minczuk, Michal, Murphy, Michael P, von Kriegsheim, Alex, Frezza, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8735863/
https://www.ncbi.nlm.nih.gov/pubmed/34939929
http://dx.doi.org/10.7554/eLife.72593

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8735863/
https://www.ncbi.nlm.nih.gov/pubmed/34939929
http://dx.doi.org/10.7554/eLife.72593

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