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Induction of serine hydroxymethyltransferase 2 promotes tumorigenesis and metastasis in neuroblastoma

High-risk neuroblastoma (NB) remains an extremely difficult subgroup to cure and is associated with MYCN amplification. Serine hydroxymethyltransferase 2 (SHMT2) regulates serine metabolism in a myc-dependent manner; it is upregulated in several cancers and is associated with tumor aggressiveness. A...

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Detalles Bibliográficos
Autores principales:	Clark, Rachael A., Qiao, Jingbo, Jacobson, Jillian C., Chung, Dai H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8735882/ https://www.ncbi.nlm.nih.gov/pubmed/35018218 http://dx.doi.org/10.18632/oncotarget.28168

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