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Caspase-2 regulates S-phase cell cycle events to protect from DNA damage accumulation independent of apoptosis
In addition to its classical role in apoptosis, accumulating evidence suggests that caspase-2 has non-apoptotic functions, including regulation of cell division. Loss of caspase-2 is known to increase proliferation rates but how caspase-2 is regulating this process is currently unclear. We show that...
Autores principales: | Boice, Ashley G., Lopez, Karla E., Pandita, Raj K, Parsons, Melissa J, Charendoff, Chloe I, Charaka, Vijay, Carisey, Alexandre F., Pandita, Tej K., Bouchier-Hayes, Lisa |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8738157/ https://www.ncbi.nlm.nih.gov/pubmed/34718349 http://dx.doi.org/10.1038/s41388-021-02085-w |
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