NKX2-1 controls lung cancer progression by inducing DUSP6 to dampen ERK activity

The RAS→RAF→MEK→ERK pathway is hyperactivated in the majority of human lung adenocarcinoma (LUAD). However, the initial activating mutations induce homeostatic feedback mechanisms that limit ERK activity. How ERK activation reaches the tumor-promoting levels that overcome the feedback and drive mali...

Descripción completa

Detalles Bibliográficos
Autores principales: Ingram, Kelley, Samson, Shiela C., Zewdu, Rediet, Zitnay, Rebecca G., Snyder, Eric L., Mendoza, Michelle C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8738158/
https://www.ncbi.nlm.nih.gov/pubmed/34689179
http://dx.doi.org/10.1038/s41388-021-02076-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8738158/
https://www.ncbi.nlm.nih.gov/pubmed/34689179
http://dx.doi.org/10.1038/s41388-021-02076-x

Ejemplares similares