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NKX2-1 controls lung cancer progression by inducing DUSP6 to dampen ERK activity
The RAS→RAF→MEK→ERK pathway is hyperactivated in the majority of human lung adenocarcinoma (LUAD). However, the initial activating mutations induce homeostatic feedback mechanisms that limit ERK activity. How ERK activation reaches the tumor-promoting levels that overcome the feedback and drive mali...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8738158/ https://www.ncbi.nlm.nih.gov/pubmed/34689179 http://dx.doi.org/10.1038/s41388-021-02076-x |