Mahogunin Ring Finger 1 regulates pigmentation by controlling the pH of melanosomes in melanocytes and melanoma cells

Mahogunin Ring Finger 1 (MGRN1) is an E3-ubiquitin ligase absent in dark-furred mahoganoid mice. We investigated the mechanisms of hyperpigmentation in Mgrn1-null melan-md1 melanocytes, Mgrn1-KO cells obtained by CRISPR-Cas9-mediated knockdown of Mgrn1 in melan-a6 melanocytes, and melan-a6 cells dep...

Descripción completa

Detalles Bibliográficos
Autores principales: Sirés-Campos, Julia, Lambertos, Ana, Delevoye, Cédric, Raposo, Graça, Bennett, Dorothy C., Sviderskaya, Elena, Jiménez-Cervantes, Celia, Olivares, Conchi, García-Borrón, José Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8738503/
https://www.ncbi.nlm.nih.gov/pubmed/34921635
http://dx.doi.org/10.1007/s00018-021-04053-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8738503/
https://www.ncbi.nlm.nih.gov/pubmed/34921635
http://dx.doi.org/10.1007/s00018-021-04053-9

Ejemplares similares