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Mahogunin Ring Finger 1 regulates pigmentation by controlling the pH of melanosomes in melanocytes and melanoma cells

Mahogunin Ring Finger 1 (MGRN1) is an E3-ubiquitin ligase absent in dark-furred mahoganoid mice. We investigated the mechanisms of hyperpigmentation in Mgrn1-null melan-md1 melanocytes, Mgrn1-KO cells obtained by CRISPR-Cas9-mediated knockdown of Mgrn1 in melan-a6 melanocytes, and melan-a6 cells dep...

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Detalles Bibliográficos
Autores principales:	Sirés-Campos, Julia, Lambertos, Ana, Delevoye, Cédric, Raposo, Graça, Bennett, Dorothy C., Sviderskaya, Elena, Jiménez-Cervantes, Celia, Olivares, Conchi, García-Borrón, José Carlos
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8738503/ https://www.ncbi.nlm.nih.gov/pubmed/34921635 http://dx.doi.org/10.1007/s00018-021-04053-9

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