Proteasome inhibition triggers the formation of TRAIL receptor 2 platforms for caspase-8 activation that accumulate in the cytosol

Cancer cells that are resistant to Bax/Bak-dependent intrinsic apoptosis can be eliminated by proteasome inhibition. Here, we show that proteasome inhibition induces the formation of high molecular weight platforms in the cytosol that serve to activate caspase-8. The activation complexes contain Fas...

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Detalles Bibliográficos
Autores principales: Hellwig, Christian T., Delgado, M. Eugenia, Skoko, Josip, Dyck, Lydia, Hanna, Carol, Wentges, Alexa, Langlais, Claudia, Hagenlocher, Cathrin, Mack, Alexandra, Dinsdale, David, Cain, Kelvin, MacFarlane, Marion, Rehm, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8738721/
https://www.ncbi.nlm.nih.gov/pubmed/34354257
http://dx.doi.org/10.1038/s41418-021-00843-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8738721/
https://www.ncbi.nlm.nih.gov/pubmed/34354257
http://dx.doi.org/10.1038/s41418-021-00843-7

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