MBD2 acts as a repressor to maintain the homeostasis of the Th1 program in type 1 diabetes by regulating the STAT1-IFN-γ axis

The methyl-CpG-binding domain 2 (MBD2) interprets DNA methylome-encoded information through binding to the methylated CpG DNA, by which it regulates target gene expression at the transcriptional level. Although derailed DNA methylation has long been recognized to trigger or promote autoimmune respon...

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Detalles Bibliográficos
Autores principales: Yue, Tiantian, Sun, Fei, Wang, Faxi, Yang, Chunliang, Luo, Jiahui, Rong, Shanjie, Zhou, Haifeng, Xiao, Jun, Wang, Xiaohui, Zhou, Qing, Yang, Ping, Zhang, Shu, Li, Wen, Xiong, Fei, Yu, Qilin, Wang, Cong-Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8738722/
https://www.ncbi.nlm.nih.gov/pubmed/34420035
http://dx.doi.org/10.1038/s41418-021-00852-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8738722/
https://www.ncbi.nlm.nih.gov/pubmed/34420035
http://dx.doi.org/10.1038/s41418-021-00852-6

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