Cargando…

MBD2 acts as a repressor to maintain the homeostasis of the Th1 program in type 1 diabetes by regulating the STAT1-IFN-γ axis

The methyl-CpG-binding domain 2 (MBD2) interprets DNA methylome-encoded information through binding to the methylated CpG DNA, by which it regulates target gene expression at the transcriptional level. Although derailed DNA methylation has long been recognized to trigger or promote autoimmune respon...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yue, Tiantian, Sun, Fei, Wang, Faxi, Yang, Chunliang, Luo, Jiahui, Rong, Shanjie, Zhou, Haifeng, Xiao, Jun, Wang, Xiaohui, Zhou, Qing, Yang, Ping, Zhang, Shu, Li, Wen, Xiong, Fei, Yu, Qilin, Wang, Cong-Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8738722/ https://www.ncbi.nlm.nih.gov/pubmed/34420035 http://dx.doi.org/10.1038/s41418-021-00852-6

Ejemplares similares

Targeted Inhibition of FTO Demethylase Protects Mice Against LPS-Induced Septic Shock by Suppressing NLRP3 Inflammasome
por: Luo, Jiahui, et al.
Publicado: (2021)

The AHR Signaling Attenuates Autoimmune Responses During the Development of Type 1 Diabetes
por: Yue, Tiantian, et al.
Publicado: (2020)

Transcriptional Repressor Domain of MBD1 is Intrinsically Disordered and Interacts with its Binding Partners in a Selective Manner
por: Hameed, Umar Farook Shahul, et al.
Publicado: (2014)

MBD5 and MBD6 stabilize the BAP1 complex and promote BAP1-dependent cancer
por: Tsuboyama, Natsumi, et al.
Publicado: (2022)

Loss of ubiquitin-conjugating enzyme E2 (Ubc9) in macrophages exacerbates multiple low-dose streptozotocin-induced diabetes by attenuating M2 macrophage polarization
por: Wang, Faxi, et al.
Publicado: (2019)

IFN-γ induces apoptosis in human melanocytes by activating the JAK1/STAT1 signaling pathway
por: Su, Qianya, et al.
Publicado: (2020)

STAT3 Regulates the Type I IFN-Mediated Antiviral Response by Interfering with the Nuclear Entry of STAT1
por: Wang, Huanru, et al.
Publicado: (2019)

IFN-β1b induces OAS3 to inhibit EV71 via IFN-β1b/JAK/STAT1 pathway
por: Zheng, Baisong, et al.
Publicado: (2022)

Single-nucleus RNA-seq reveals that MBD5, MBD6, and SILENZIO maintain silencing in the vegetative cell of developing pollen
por: Ichino, Lucia, et al.
Publicado: (2022)

The functional duality of SGK1 in the regulation of hyperglycemia
por: Yang, Chunliang, et al.
Publicado: (2020)

Loss of MBD2 attenuates MLL-AF9-driven leukemogenesis by suppressing the leukemic cell cycle via CDKN1C
por: Zhou, Kuangguo, et al.
Publicado: (2021)

STAT1 maintains naïve CD8(+) T cell quiescence by suppressing the type I IFN-STAT4-mTORC1 signaling axis
por: Kye, Yoon-Chul, et al.
Publicado: (2021)

Extracellular HMGB1 exacerbates autoimmune progression and recurrence of type 1 diabetes by impairing regulatory T cell stability
por: Zhang, Jing, et al.
Publicado: (2020)

Solution structure of human MBD1 CXXC1
por: Thomson, Ross, et al.
Publicado: (2015)

Nuclear Receptor CoRepressors, NCOR1 and SMRT, are required for maintaining systemic metabolic homeostasis
por: Ritter, Megan J., et al.
Publicado: (2021)

Expression of Interferon Effector Gene SART1 Correlates with Interferon Treatment Response against Hepatitis B Infection
por: Li, Yong, et al.
Publicado: (2016)

Recruitment of MBD1 to target genes requires sequence-specific interaction of the MBD domain with methylated DNA
por: Clouaire, Thomas, et al.
Publicado: (2010)

MBD2 serves as a viable target against pulmonary fibrosis by inhibiting macrophage M2 program
por: Wang, Yi, et al.
Publicado: (2021)

Glioma stem-like cells evade interferon suppression through MBD3/NuRD complex–mediated STAT1 downregulation
por: Zhan, Xiaoyan, et al.
Publicado: (2020)

Role of STAT1 in the resistance of HBV to IFN-α
por: Xu, Bingfa, et al.
Publicado: (2021)

Toxoplasma gondii TgIST co-opts host chromatin repressors dampening STAT1-dependent gene regulation and IFN-γ–mediated host defenses
por: Gay, Gabrielle, et al.
Publicado: (2016)

Trapping MBD5 to understand 2q23.1 microdeletion syndrome
por: Kwon, Deborah Y, et al.
Publicado: (2014)

Interactions between Th1 cells and Tregs affect regulation of hepatic fibrosis in biliary atresia through the IFN-γ/STAT1 pathway
por: Wen, Jie, et al.
Publicado: (2017)

SUMOylation of PDPK1 Is required to maintain glycolysis-dependent CD4 T-cell homeostasis
por: Sun, Fei, et al.
Publicado: (2022)

Down-regulation of DNA key protein-FEN1 inhibits OSCC growth by affecting immunosuppressive phenotypes via IFN-γ/JAK/STAT-1
por: Wang, Shimeng, et al.
Publicado: (2023)

MBD2 facilitates tumor metastasis by mitigating DDB2 expression
por: Zhang, Lei, et al.
Publicado: (2023)

MBD2 and MBD3: elusive functions and mechanisms
por: Menafra, Roberta, et al.
Publicado: (2014)

Erratum. Loss of Mbd2 Protects Mice Against High-Fat Diet–Induced Obesity and Insulin Resistance by Regulating the Homeostasis of Energy Storage and Expenditure. Diabetes 2016;65:3384–3395
por: Cheng, Jia, et al.
Publicado: (2017)

The TIE1 transcriptional repressor controls shoot branching by directly repressing BRANCHED1 in Arabidopsis
por: Yang, Yan, et al.
Publicado: (2018)

The Endothelium Is in Shock and IFN-α/STAT1 Signaling Is to Blame
por: Farkas, Laszlo
Publicado: (2021)

Retraction Note: Interactions between Th1 cells and Tregs affect regulation of hepatic fibrosis in biliary atresia through the IFN-γ/STAT1 pathway
por: Wen, Jie, et al.
Publicado: (2019)

Active Components with Inhibitory Activities on IFN-γ/STAT1 and IL-6/STAT3 Signaling Pathways from Caulis Trachelospermi
por: Liu, Xiao-Ting, et al.
Publicado: (2014)

Construction of Eukaryotic Expression Vector with mBD1-mBD3 Fusion Genes and Exploring Its Activity against Influenza A Virus
por: Li, Wanyi, et al.
Publicado: (2014)

ERK is a negative feedback regulator for IFN-γ/STAT1 signaling by promoting STAT1 ubiquitination
por: Zhang, Ying, et al.
Publicado: (2018)

Correction: The TIE1 transcriptional repressor controls shoot branching by directly repressing BRANCHED1 in Arabidopsis
por: Yang, Yan, et al.
Publicado: (2018)

Anti-PD1 up-regulates PD-L1 expression and inhibits T-cell lymphoma progression: possible involvement of an IFN-γ-associated JAK-STAT pathway
por: Xue, Weili, et al.
Publicado: (2019)

Inherited 2q23.1 microdeletions involving the MBD5 locus
por: Tadros, Shereen, et al.
Publicado: (2017)

Hsa-miR-31 Governs T-Cell Homeostasis in HIV Protection via IFN-γ-Stat1-T-Bet Axis
por: Zhu, Lingyan, et al.
Publicado: (2021)

An Epigenetic Regulator: Methyl-CpG-Binding Domain Protein 1 (MBD1)
por: Li, Lu, et al.
Publicado: (2015)

IFNγ-Stat1 axis drives aging-associated loss of intestinal tissue homeostasis and regeneration
por: Omrani, Omid, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_m3t0sm8m1qhkbhqfm9u1hlfpj5