Lactate promotes macrophage HMGB1 lactylation, acetylation, and exosomal release in polymicrobial sepsis

High circulating levels of lactate and high mobility group box-1 (HMGB1) are associated with the severity and mortality of sepsis. However, it is unclear whether lactate could promote HMGB1 release during sepsis. The present study demonstrated a novel role of lactate in HMGB1 lactylation and acetyla...

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Detalles Bibliográficos
Autores principales: Yang, Kun, Fan, Min, Wang, Xiaohui, Xu, Jingjing, Wang, Yana, Tu, Fei, Gill, P. Spencer, Ha, Tuanzhu, Liu, Li, Williams, David L., Li, Chuanfu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8738735/
https://www.ncbi.nlm.nih.gov/pubmed/34363018
http://dx.doi.org/10.1038/s41418-021-00841-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8738735/
https://www.ncbi.nlm.nih.gov/pubmed/34363018
http://dx.doi.org/10.1038/s41418-021-00841-9

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