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Sustained intracellular calcium rise mediates neuronal mitophagy in models of autosomal dominant optic atrophy
Mitochondrial dysfunction and mitophagy are often hallmarks of neurodegenerative diseases such as autosomal dominant optic atrophy (ADOA) caused by mutations in the key mitochondrial dynamics protein optic atrophy 1 (Opa1). However, the second messengers linking mitochondrial dysfunction to initiati...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8738763/ https://www.ncbi.nlm.nih.gov/pubmed/34389813 http://dx.doi.org/10.1038/s41418-021-00847-3 |