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Sustained intracellular calcium rise mediates neuronal mitophagy in models of autosomal dominant optic atrophy

Mitochondrial dysfunction and mitophagy are often hallmarks of neurodegenerative diseases such as autosomal dominant optic atrophy (ADOA) caused by mutations in the key mitochondrial dynamics protein optic atrophy 1 (Opa1). However, the second messengers linking mitochondrial dysfunction to initiati...

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Detalles Bibliográficos
Autores principales: Zaninello, Marta, Palikaras, Konstantinos, Sotiriou, Aggeliki, Tavernarakis, Nektarios, Scorrano, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8738763/
https://www.ncbi.nlm.nih.gov/pubmed/34389813
http://dx.doi.org/10.1038/s41418-021-00847-3