Activation of neutral sphingomyelinase 2 through hyperglycemia contributes to endothelial apoptosis via vesicle-bound intercellular transfer of ceramides

BACKGROUND: Pro-apoptotic and pro-inflammatory ceramides are crucially involved in atherosclerotic plaque development. Local cellular ceramide accumulation mediates endothelial apoptosis, especially in type 2 diabetes mellitus, which is a major cardiovascular risk factor. In recent years, large extr...

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Detalles Bibliográficos
Autores principales: Zietzer, Andreas, Jahnel, Alina Lisann, Bulic, Marko, Gutbrod, Katharina, Düsing, Philip, Hosen, Mohammed Rabiul, Dörmann, Peter, Werner, Nikos, Nickenig, Georg, Jansen, Felix
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8739297/
https://www.ncbi.nlm.nih.gov/pubmed/34951654
http://dx.doi.org/10.1007/s00018-021-04049-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8739297/
https://www.ncbi.nlm.nih.gov/pubmed/34951654
http://dx.doi.org/10.1007/s00018-021-04049-5

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