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Activation of neutral sphingomyelinase 2 through hyperglycemia contributes to endothelial apoptosis via vesicle-bound intercellular transfer of ceramides

BACKGROUND: Pro-apoptotic and pro-inflammatory ceramides are crucially involved in atherosclerotic plaque development. Local cellular ceramide accumulation mediates endothelial apoptosis, especially in type 2 diabetes mellitus, which is a major cardiovascular risk factor. In recent years, large extr...

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Detalles Bibliográficos
Autores principales:	Zietzer, Andreas, Jahnel, Alina Lisann, Bulic, Marko, Gutbrod, Katharina, Düsing, Philip, Hosen, Mohammed Rabiul, Dörmann, Peter, Werner, Nikos, Nickenig, Georg, Jansen, Felix
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8739297/ https://www.ncbi.nlm.nih.gov/pubmed/34951654 http://dx.doi.org/10.1007/s00018-021-04049-5

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