Non-invasive administration of AAV to target lung parenchymal cells and develop SARS-CoV-2-susceptible mice

Adeno-associated virus (AAV)-mediated gene delivery holds great promise for gene therapy. However, the non-invasive delivery of AAV for lung tissues has not been adequately established. Here, we revealed that the intratracheal administration of an appropriate amount of AAV2/8 predominantly targets l...

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Detalles Bibliográficos
Autores principales: Yang, Myeon-Sik, Park, Min-Jung, Lee, Junhyeong, Oh, Byungkwan, Kang, Kyung Won, Kim, Yeonhwa, Lee, Sang-Myeong, Lim, Je-Oh, Jung, Tae-Yang, Park, Jong-Hwan, Park, Seok-Chan, Lim, Yun-Sook, Hwang, Soon B., Lyoo, Kwang-Soo, Kim, Dong-il, Kim, Bumseok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8739362/
https://www.ncbi.nlm.nih.gov/pubmed/35007757
http://dx.doi.org/10.1016/j.ymthe.2022.01.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8739362/
https://www.ncbi.nlm.nih.gov/pubmed/35007757
http://dx.doi.org/10.1016/j.ymthe.2022.01.010

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