Cargando…
ADAR1 RNA editing regulates endothelial cell functions via the MDA-5 RNA sensing signaling pathway
The RNA-sensing signaling pathway has been well studied as an essential antiviral mechanism of innate immunity. However, its role in non-infected cells is yet to be thoroughly characterized. Here, we demonstrated that the RNA sensing signaling pathway also reacts to the endogenous cellular RNAs in e...
Autores principales: | Guo, Xinfeng, Liu, Silvia, Yan, Rose, Nguyen, Vy, Zenati, Mazen, Billiar, Timothy R, Wang, Qingde |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Life Science Alliance LLC
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8739526/ https://www.ncbi.nlm.nih.gov/pubmed/34969816 http://dx.doi.org/10.26508/lsa.202101191 |
Ejemplares similares
-
ADAR1 Zα domain P195A mutation activates the MDA5-dependent RNA-sensing signaling pathway in brain without decreasing overall RNA editing
por: Guo, Xinfeng, et al.
Publicado: (2023) -
RNA Editing, ADAR1, and the Innate Immune Response
por: Wang, Qingde, et al.
Publicado: (2017) -
ADAR1 Suppresses the Activation of Cytosolic RNA-Sensing Signaling Pathways to Protect the Liver from Ischemia/Reperfusion Injury
por: Wang, Hui, et al.
Publicado: (2016) -
RNA editing enzyme ADAR1 is required for early T cell development
por: Xufeng, Richard, et al.
Publicado: (2020) -
An AGS-associated mutation in ADAR1 catalytic domain results in early-onset and MDA5-dependent encephalopathy with IFN pathway activation in the brain
por: Guo, Xinfeng, et al.
Publicado: (2022)