Loss-of-function mutation in Pcsk1 increases serum APOA1 level and LCAT activity in mice

BACKGROUND: The convertase subtilisin/kexin family 1 gene (PCSK1) has been associated in various human genetics studies with a wide spectrum of metabolic phenotypes, including early-onset obesity, hyperphagia, diabetes insipidus, and others. Despite the evident influence of PCSK1 on obesity and the...

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Detalles Bibliográficos
Autores principales: Khan, Aleksandra Aljakna, Kim, Nakyung, Korstanje, Ron, Choi, Seungbum
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8739671/
https://www.ncbi.nlm.nih.gov/pubmed/34996527
http://dx.doi.org/10.1186/s42826-021-00111-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8739671/
https://www.ncbi.nlm.nih.gov/pubmed/34996527
http://dx.doi.org/10.1186/s42826-021-00111-2

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