Cargando…

Loss-of-function mutation in Pcsk1 increases serum APOA1 level and LCAT activity in mice

BACKGROUND: The convertase subtilisin/kexin family 1 gene (PCSK1) has been associated in various human genetics studies with a wide spectrum of metabolic phenotypes, including early-onset obesity, hyperphagia, diabetes insipidus, and others. Despite the evident influence of PCSK1 on obesity and the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Khan, Aleksandra Aljakna, Kim, Nakyung, Korstanje, Ron, Choi, Seungbum
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8739671/ https://www.ncbi.nlm.nih.gov/pubmed/34996527 http://dx.doi.org/10.1186/s42826-021-00111-2

Ejemplares similares

Decreased APOE-containing HDL subfractions and cholesterol efflux capacity of serum in mice lacking Pcsk9
por: Choi, Seungbum, et al.
Publicado: (2013)

An apoA-I mimetic peptide increases LCAT activity in mice through increasing HDL concentration
por: Chen, Xun, et al.
Publicado: (2009)

LCAT, ApoD, and ApoA1 Expression and Review of Cholesterol Deposition in the Cornea
por: Flores, Rhonda, et al.
Publicado: (2019)

The effect of weight loss on HDL subfractions and LCAT activity in two genotypes of APOA-II -265T>C polymorphism
por: Moradi, Masoumeh, et al.
Publicado: (2017)

Pla2g12b and Hpn Are Genes Identified by Mouse ENU Mutagenesis That Affect HDL Cholesterol
por: Aljakna, Aleksandra, et al.
Publicado: (2012)

Lipid Profile Rather Than the LCAT Mutation Explains Renal Disease in Familial LCAT Deficiency
por: Lamiquiz-Moneo, Itziar, et al.
Publicado: (2019)

Proprotein convertases in high-density lipoprotein metabolism
por: Choi, Seungbum, et al.
Publicado: (2013)

First-in-human autologous implantation of genetically modified adipocytes expressing LCAT for the treatment of familial LCAT deficiency
por: Aso, Masayuki, et al.
Publicado: (2022)

Adrenal Function in Females with Low Plasma HDL-C Due to Mutations in ABCA1 and LCAT
por: Bochem, Andrea E., et al.
Publicado: (2014)

Serum Levels of ApoA1 and ApoA2 Are Associated with Cognitive Status in Older Men
por: Ma, Cheng, et al.
Publicado: (2015)

Current Status of Familial LCAT Deficiency in Japan
por: Kuroda, Masayuki, et al.
Publicado: (2021)

An unusual presentation of LCAT deficiency as nephrotic syndrome with normal serum HDL-C level
por: Balwani, Manish R, et al.
Publicado: (2016)

HDL/ApoA-1 infusion and ApoA-1 gene therapy in atherosclerosis
por: Chyu, Kuang-Yuh, et al.
Publicado: (2015)

Lipoprotein X Causes Renal Disease in LCAT Deficiency
por: Ossoli, Alice, et al.
Publicado: (2016)

Toxoplasma gondii LCAT Primarily Contributes to Tachyzoite Egress
por: Schultz, Aric J., et al.
Publicado: (2018)

rHDL modeling and the anchoring mechanism of LCAT activation
por: Laurenzi, Tommaso, et al.
Publicado: (2020)

Association of BUD13-ZNF259-APOA5-APOA1-SIK3 cluster polymorphism in 11q23.3 and structure of APOA5 with increased plasma triglyceride levels in a Korean population
por: Kim, Han-Kyul, et al.
Publicado: (2019)

Role of apolipoproteins, ABCA1 and LCAT in the biogenesis of normal and aberrant high density lipoproteins
por: Zannis, Vassilis I., et al.
Publicado: (2017)

Interactions of Environmental Factors and APOA1-APOC3-APOA4-APOA5 Gene Cluster Gene Polymorphisms with Metabolic Syndrome
por: Wu, Yanhua, et al.
Publicado: (2016)

SIDT2 Associates with Apolipoprotein A1 (ApoA1) and Facilitates ApoA1 Secretion in Hepatocytes
por: Sampieri, Alicia, et al.
Publicado: (2023)

Allele-specific enhancers mediate associations between LCAT and ABCA1 polymorphisms and HDL metabolism
por: Howard, Alicia D., et al.
Publicado: (2019)

Two novel mutations of lecithin:cholesterol acyltransferase (LCAT) gene and the influence of APOE genotypes on clinical manifestations
por: Katayama, Akihiro, et al.
Publicado: (2011)

Familial lecithin-cholesterol acyltransferase (LCAT) deficiency; a differential of proteinuria
por: Althaf, Mohammed Mahdi, et al.
Publicado: (2015)

LCAT: an isoform-sensitive error correction for transcriptome sequencing long reads
por: Zhu, Wufei, et al.
Publicado: (2023)

LCAT1 is an oncogenic LncRNA by stabilizing the IGF2BP2-CDC6 axis
por: Yang, Juze, et al.
Publicado: (2022)

ApoA-1 in Diabetes: Damaged Goods
por: Ory, Daniel S., et al.
Publicado: (2010)

APOA1 Is a Novel Marker for Preeclampsia
por: Liu, Zhenzhen, et al.
Publicado: (2023)

Novel N-terminal mutation of human apolipoprotein A-I reduces self-association and impairs LCAT activation
por: Weers, Paul M. M., et al.
Publicado: (2011)

Differential effects of PCSK9 loss of function variants on serum lipid and PCSK9 levels in Caucasian and African Canadian populations
por: Mayne, Janice, et al.
Publicado: (2013)

Decreased expression of the APOA1–APOC3–APOA4 gene cluster is associated with risk of Alzheimer’s disease
por: Lin, Qiao, et al.
Publicado: (2015)

PCSK9 Is Increased in Youth With Type 1 Diabetes
por: Levenson, Amy E., et al.
Publicado: (2017)

Label-Free Electrochemiluminescence Nano-aptasensor for the Ultrasensitive Detection of ApoA1 in Human Serum
por: Kurup, Chitra P., et al.
Publicado: (2022)

LCAT deficiency: a systematic review with the clinical and genetic description of Mexican kindred
por: Mehta, Roopa, et al.
Publicado: (2021)

Association between the APOA2 rs3813627 Single Nucleotide Polymorphism and HDL and APOA1 Levels Through BMI
por: Boughanem, Hatim, et al.
Publicado: (2020)

The Variants at APOA1 and APOA4 Contribute to the Susceptibility of Schizophrenia With Inhibiting mRNA Expression in Peripheral Blood Leukocytes
por: Fan, Yao, et al.
Publicado: (2021)

The Correlation between Serum ApoA1 and B and Coronary Artery Disease as Well as Its Severity
por: Mashayekhi, Navid Reza, et al.
Publicado: (2014)

Association of the APOA1 rs964184 SNP and serum lipid traits in the Chinese Maonan and Han populations
por: Qiu, Ling, et al.
Publicado: (2018)

Low Plasma Lecithin: Cholesterol Acyltransferase (LCAT) Concentration Predicts Chronic Kidney Disease
por: Baragetti, Andrea, et al.
Publicado: (2020)

Metabolism of PLTP, CETP, and LCAT on multiple HDL sizes using the Orbitrap Fusion Lumos
por: Singh, Sasha A., et al.
Publicado: (2021)

Two novel variants in the lecithin:cholesterol acyltransferase gene resulted in classic LCAT deficiency
por: Fistrek Prlic, Margareta, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_45oqp1rqmq558ra24eona3k7vd