Constitutively active SARM1 variants that induce neuropathy are enriched in ALS patients

BACKGROUND: In response to injury, neurons activate a program of organized axon self-destruction initiated by the NAD(+) hydrolase, SARM1. In healthy neurons SARM1 is autoinhibited, but single amino acid changes can abolish autoinhibition leading to constitutively active SARM1 enzymes that promote d...

Descripción completa

Detalles Bibliográficos
Autores principales: Bloom, A. Joseph, Mao, Xianrong, Strickland, Amy, Sasaki, Yo, Milbrandt, Jeffrey, DiAntonio, Aaron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8739729/
https://www.ncbi.nlm.nih.gov/pubmed/34991663
http://dx.doi.org/10.1186/s13024-021-00511-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8739729/
https://www.ncbi.nlm.nih.gov/pubmed/34991663
http://dx.doi.org/10.1186/s13024-021-00511-x

Ejemplares similares