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Constitutively active SARM1 variants that induce neuropathy are enriched in ALS patients
BACKGROUND: In response to injury, neurons activate a program of organized axon self-destruction initiated by the NAD(+) hydrolase, SARM1. In healthy neurons SARM1 is autoinhibited, but single amino acid changes can abolish autoinhibition leading to constitutively active SARM1 enzymes that promote d...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8739729/ https://www.ncbi.nlm.nih.gov/pubmed/34991663 http://dx.doi.org/10.1186/s13024-021-00511-x |