Detection and quantitation of host cell proteins in monoclonal antibody drug products using automated sample preparation and data-independent acquisition LC-MS/MS

Ensuring the removal of host cell proteins (HCPs) during downstream processing of recombinant proteins such as monoclonal antibodies (mAbs) remains a challenge. Since residual HCPs might affect product stability or safety, constant monitoring is required to demonstrate their removal to be below the...

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Detalles Bibliográficos
Autores principales: Strasser, Lisa, Oliviero, Giorgio, Jakes, Craig, Zaborowska, Izabela, Floris, Patrick, Ribeiro da Silva, Meire, Füssl, Florian, Carillo, Sara, Bones, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Xi'an Jiaotong University 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8740166/
https://www.ncbi.nlm.nih.gov/pubmed/35028177
http://dx.doi.org/10.1016/j.jpha.2021.05.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8740166/
https://www.ncbi.nlm.nih.gov/pubmed/35028177
http://dx.doi.org/10.1016/j.jpha.2021.05.002

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