Cargando…

Latent Transforming Growth Factor-β Binding Protein-2 Regulates Lung Fibroblast-to-Myofibroblast Differentiation in Pulmonary Fibrosis via NF-κB Signaling

Despite past extensive studies, the mechanisms underlying pulmonary fibrosis (PF) still remain poorly understood. The aberrantly activated lung myofibroblasts, predominantly emerging through fibroblast-to-myofibroblast differentiation, are considered to be the key cells in PF, resulting in excessive...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zou, Menglin, Zou, Jingfeng, Hu, Xingxing, Zheng, Weishuai, Zhang, Mingyang, Cheng, Zhenshun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8740300/ https://www.ncbi.nlm.nih.gov/pubmed/35002722 http://dx.doi.org/10.3389/fphar.2021.788714

Ejemplares similares

Dec1 Deficiency Ameliorates Pulmonary Fibrosis Through the PI3K/AKT/GSK-3β/β-Catenin Integrated Signaling Pathway
por: Hu, Xingxing, et al.
Publicado: (2022)

Anlotinib Inhibits PFKFB3-Driven Glycolysis in Myofibroblasts to Reverse Pulmonary Fibrosis
por: Chen, Weimou, et al.
Publicado: (2021)

Curcumin Inhibits Transforming Growth Factor β Induced Differentiation of Mouse Lung Fibroblasts to Myofibroblasts
por: Liu, Daishun, et al.
Publicado: (2016)

Cepharanthine Ameliorates Pulmonary Fibrosis by Inhibiting the NF-κB/NLRP3 Pathway, Fibroblast-to-Myofibroblast Transition and Inflammation
por: Chen, Guangrui, et al.
Publicado: (2023)

In Vivo Activation and Pro-Fibrotic Function of NF-κB in Fibroblastic Cells During Pulmonary Inflammation and Fibrosis Induced by Carbon Nanotubes
por: Dong, Jie, et al.
Publicado: (2019)

Pharmacological Inhibition of STING/TBK1 Signaling Attenuates Myeloid Fibroblast Activation and Macrophage to Myofibroblast Transition in Renal Fibrosis
por: Zeng, Haimei, et al.
Publicado: (2022)

The types of hepatic myofibroblasts contributing to liver fibrosis of different etiologies
por: Xu, Jun, et al.
Publicado: (2014)

Phosphatidylethanolamine-binding protein 4 deficiency exacerbates carbon tetrachloride-induced liver fibrosis by regulating the NF-κB signaling pathway
por: Luo, Qianqian, et al.
Publicado: (2022)

Vincristine Promotes Transdifferentiation of Fibroblasts Into Myofibroblasts via P38 and ERK Signal Pathways
por: Xu, Hui, et al.
Publicado: (2022)

Anti-Rheumatic Properties of Gentiopicroside Are Associated With Suppression of ROS-NF-κB-NLRP3 Axis in Fibroblast-Like Synoviocytes and NF-κB Pathway in Adjuvant-Induced Arthritis
por: Wang, Meiling, et al.
Publicado: (2020)

ADAM17 knockdown mitigates while ADAM17 overexpression aggravates cardiac fibrosis and dysfunction via regulating ACE2 shedding and myofibroblast transformation
por: Cheng, Jing, et al.
Publicado: (2022)

MYH9 Inhibition Suppresses TGF-β1-Stimulated Lung Fibroblast-to-Myofibroblast Differentiation
por: Sun, Xionghua, et al.
Publicado: (2021)

APOC1 exacerbates renal fibrosis through the activation of the NF-κB signaling pathway in IgAN
por: Yu, Kuipeng, et al.
Publicado: (2023)

Long Non-coding RNAs Rian and Miat Mediate Myofibroblast Formation in Kidney Fibrosis
por: Bijkerk, Roel, et al.
Publicado: (2019)

Eplerenone Attenuates Fibrosis in the Contralateral Kidney of UUO Rats by Preventing Macrophage-to-Myofibroblast Transition
por: Xiong, Yunzhao, et al.
Publicado: (2021)

Baiying qingmai formulation ameliorates thromboangiitis obliterans by inhibiting HMGB1/RAGE/NF-κB signaling pathways
por: Zou, Chongchong, et al.
Publicado: (2022)

The methyl-CpG-binding domain 2 facilitates pulmonary fibrosis by orchestrating fibroblast to myofibroblast differentiation
por: Wang, Yi, et al.
Publicado: (2022)

An Herbal Product Alleviates Bleomycin-Induced Pulmonary Fibrosis in Mice via Regulating NF-κB/TNF-α Signaling in Macrophages
por: Jing, Fei, et al.
Publicado: (2022)

Heterogeneity in fibroblast proliferation and survival in idiopathic pulmonary fibrosis
por: Habiel, David M., et al.
Publicado: (2014)

Umbelliferone and scopoletin target tyrosine kinases on fibroblast-like synoviocytes to block NF-κB signaling to combat rheumatoid arthritis
por: Chen, Qilei, et al.
Publicado: (2022)

Sophocarpine Suppresses NF-κB-Mediated Inflammation Both In Vitro and In Vivo and Inhibits Diabetic Cardiomyopathy
por: Zou, Fang, et al.
Publicado: (2019)

Pirfenidone and nintedanib modulate properties of fibroblasts and myofibroblasts in idiopathic pulmonary fibrosis
por: Lehtonen, Siri T., et al.
Publicado: (2016)

EZH2 enhances the differentiation of fibroblasts into myofibroblasts in idiopathic pulmonary fibrosis
por: Xiao, Xiao, et al.
Publicado: (2016)

miR‐21 promotes cardiac fibroblast‐to‐myofibroblast transformation and myocardial fibrosis by targeting Jagged1
por: Zhou, Xue‐liang, et al.
Publicado: (2018)

Targeting Gremlin 1 Prevents Intestinal Fibrosis Progression by Inhibiting the Fatty Acid Oxidation of Fibroblast Cells
por: Yang, Yang, et al.
Publicado: (2021)

Fibroblasts in fibrosis: novel roles and mediators
por: Kendall, Ryan T., et al.
Publicado: (2014)

Sappanone a prevents diabetic kidney disease by inhibiting kidney inflammation and fibrosis via the NF-κB signaling pathway
por: Wang, Zhe, et al.
Publicado: (2022)

Gentiopicroside Ameliorates Diabetic Renal Tubulointerstitial Fibrosis via Inhibiting the AT1R/CK2/NF-κB Pathway
por: Xu, Zhanchi, et al.
Publicado: (2022)

Polyporus Polysaccharide Ameliorates Bleomycin-Induced Pulmonary Fibrosis by Suppressing Myofibroblast Differentiation via TGF-β/Smad2/3 Pathway
por: Jiang, Jintao, et al.
Publicado: (2020)

Noncoding RNAs: Master Regulator of Fibroblast to Myofibroblast Transition in Fibrosis
por: Zhang, Huamin, et al.
Publicado: (2023)

TRAF6 Suppresses the Development of Pulmonary Fibrosis by Attenuating the Activation of Fibroblasts
por: Min, Jiali, et al.
Publicado: (2022)

Aspirin Attenuates Cardiac Allograft Rejection by Inhibiting the Maturation of Dendritic Cells via the NF-κB Signaling Pathway
por: Zhang, Xi, et al.
Publicado: (2021)

Antifibrotic Effects of a Barbituric Acid Derivative on Liver Fibrosis by Blocking the NF-κB Signaling Pathway in Hepatic Stellate Cells
por: Wang, Yuan-Hsi, et al.
Publicado: (2020)

NOX1 promotes myocardial fibrosis and cardiac dysfunction via activating the TLR2/NF-κB pathway in diabetic cardiomyopathy
por: Zhang, Dandan, et al.
Publicado: (2022)

Schizandrin C regulates lipid metabolism and inflammation in liver fibrosis by NF-κB and p38/ERK MAPK signaling pathways
por: Chen, Panpan, et al.
Publicado: (2023)

Extracellular HSP90α Interacts With ER Stress to Promote Fibroblasts Activation Through PI3K/AKT Pathway in Pulmonary Fibrosis
por: Zhang, Jinming, et al.
Publicado: (2021)

HMGB1 induces lung fibroblast to myofibroblast differentiation through NF-κB-mediated TGF-β1 release
por: Wang, Qiong, et al.
Publicado: (2017)

Ability to Suppress TGF-β-Activated Myofibroblast Differentiation Distinguishes the Anti-pulmonary Fibrosis Efficacy of Two Danshen-Containing Chinese Herbal Medicine Prescriptions
por: Shao, Rui, et al.
Publicado: (2019)

Isochlorogenic Acid A Attenuates the Progression of Liver Fibrosis Through Regulating HMGB1/TLR4/NF-κB Signaling Pathway
por: Liu, Xin, et al.
Publicado: (2020)

Hydrogen sulphide suppresses human atrial fibroblast proliferation and transformation to myofibroblasts
por: Sheng, Jingwei, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_4d45k2rv1j9v9hftgksk7fv60g