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HIV-1 hypermethylated guanosine cap licenses specialized translation unaffected by mTOR
Appended to the 5′ end of nascent RNA polymerase II transcripts is 7-methyl guanosine (m(7)G-cap) that engages nuclear cap-binding complex (CBC) to facilitate messenger RNA (mRNA) maturation. Mature mRNAs exchange CBC for eIF4E, the rate-limiting translation factor that is controlled through mTOR. E...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8740576/ https://www.ncbi.nlm.nih.gov/pubmed/34949712 http://dx.doi.org/10.1073/pnas.2105153118 |