A synergy between mechanosensitive calcium- and membrane-binding mediates tension-sensing by C2-like domains

When nuclear membranes are stretched, the peripheral membrane enzyme cytosolic phospholipase A2 (cPLA(2)) binds via its calcium-dependent C2 domain (cPLA(2)-C2) and initiates bioactive lipid signaling and tissue inflammation. More than 150 C2-like domains are encoded in vertebrate genomes. How many...

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Detalles Bibliográficos
Autores principales: Shen, Zhouyang, Belcheva, Kalina T., Jelcic, Mark, Hui, King Lam, Katikaneni, Anushka, Niethammer, Philipp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8740744/
https://www.ncbi.nlm.nih.gov/pubmed/34969839
http://dx.doi.org/10.1073/pnas.2112390119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8740744/
https://www.ncbi.nlm.nih.gov/pubmed/34969839
http://dx.doi.org/10.1073/pnas.2112390119

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