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A synergy between mechanosensitive calcium- and membrane-binding mediates tension-sensing by C2-like domains
When nuclear membranes are stretched, the peripheral membrane enzyme cytosolic phospholipase A2 (cPLA(2)) binds via its calcium-dependent C2 domain (cPLA(2)-C2) and initiates bioactive lipid signaling and tissue inflammation. More than 150 C2-like domains are encoded in vertebrate genomes. How many...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8740744/ https://www.ncbi.nlm.nih.gov/pubmed/34969839 http://dx.doi.org/10.1073/pnas.2112390119 |