Translational Pharmacokinetic–Pharmacodynamic Modeling of NaV1.7 Inhibitor MK-2075 to Inform Human Efficacious Dose

MK-2075 is a small-molecule selective inhibitor of the NaV1.7 channel investigated for the treatment of postoperative pain. A translational strategy was developed for MK-2075 to quantitatively interrelate drug exposure, target modulation, and the desired pharmacological response in preclinical anima...

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Detalles Bibliográficos
Autores principales: Ballard, Jeanine E., Pall, Parul S., Vardigan, Joshua, Zhao, Fuqiang, Holahan, Marie A., Zhou, Xiaoping, Jochnowitz, Nina, Kraus, Richard L., Klein, Rebecca M., Henze, Darrell A., Houghton, Andrea K., Burgey, Christopher S., Gibson, Christopher, Struyk, Arie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8740778/
https://www.ncbi.nlm.nih.gov/pubmed/35002718
http://dx.doi.org/10.3389/fphar.2021.786078

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8740778/
https://www.ncbi.nlm.nih.gov/pubmed/35002718
http://dx.doi.org/10.3389/fphar.2021.786078

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