CRISPR/Cas9-mediated Bag-1 knockout increased mesenchymal characteristics of MCF-7 cells via Akt hyperactivation-mediated actin cytoskeleton remodeling

Bag-1 protein is a crucial target in cancer to increase the survival and proliferation of cells. The Bag-1 expression is significantly upregulated in primary and metastatic cancer patients compared to normal breast tissue. Overexpression of Bag-1 decreases the efficiency of conventional chemotherape...

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Detalles Bibliográficos
Autores principales: Kilbas, Pelin Ozfiliz, Can, Nisan Denizce, Kizilboga, Tugba, Ezberci, Fikret, Doganay, Hamdi Levent, Arisan, Elif Damla, Dinler Doganay, Gizem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741009/
https://www.ncbi.nlm.nih.gov/pubmed/34995286
http://dx.doi.org/10.1371/journal.pone.0261062

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741009/
https://www.ncbi.nlm.nih.gov/pubmed/34995286
http://dx.doi.org/10.1371/journal.pone.0261062

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