Cargando…

O-linked α2,3 sialylation defines stem cell populations in breast cancer

We pursued the hypothesis that specific glycans can be used to distinguish breast cancer stem cells (CSCs) and influence their function. Comparison of CSCs and non-CSCs from multiple breast cancer models revealed that CSCs are distinguished by expression of α2,3 sialylated core2 O-linked glycans. We...

Descripción completa

Detalles Bibliográficos
Autores principales:	Walker, Melanie R., Goel, Hira Lal, Mukhopadhyay, Dimpi, Chhoy, Peter, Karner, Emmet R., Clark, Jennifer L., Liu, Haibo, Li, Rui, Zhu, Julie Lihua, Chen, Shuhui, Mahal, Lara K., Bensing, Barbara A., Mercurio, Arthur M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741191/ https://www.ncbi.nlm.nih.gov/pubmed/34995107 http://dx.doi.org/10.1126/sciadv.abj9513

Ejemplares similares

Targeting prominin2 transcription to overcome ferroptosis resistance in cancer
por: Brown, Caitlin W, et al.
Publicado: (2021)

N-acetylneuraminate pyruvate lyase controls sialylation of muscle glycoproteins essential for muscle regeneration and function
por: Da Silva, Afitz, et al.
Publicado: (2023)

SEC23A rescues SEC23B-deficient congenital dyserythropoietic anemia type II
por: King, Richard, et al.
Publicado: (2021)

The Human Proteoform Project: Defining the human proteome
por: Smith, Lloyd M., et al.
Publicado: (2021)

Subcellular location defines GPCR signal transduction
por: Radoux-Mergault, Arthur, et al.
Publicado: (2023)

Multiple approaches of cellular metabolism define the bacterial ancestry of mitochondria
por: Geiger, Otto, et al.
Publicado: (2023)

A programmable high-expression yeast platform responsive to user-defined signals
por: Liu, Qi, et al.
Publicado: (2022)

High-temperature adaptation of an OsNRT2.3 allele is thermoregulated by small RNAs
por: Zhang, Yong, et al.
Publicado: (2022)

Neural network learning defines glioblastoma features to be of neural crest perivascular or radial glia lineages
por: Hu, Yizhou, et al.
Publicado: (2022)

RSPO2 defines a distinct undifferentiated progenitor in the tendon/ligament and suppresses ectopic ossification
por: Tachibana, Naohiro, et al.
Publicado: (2022)

Modification of maternally defined H3K4me3 regulates the inviability of interspecific Xenopus hybrids
por: Long, Qi, et al.
Publicado: (2023)

The p23 co-chaperone is a succinate-activated COX-2 transcription factor in lung adenocarcinoma tumorigenesis
por: Yu, Zhenlong, et al.
Publicado: (2023)

The STEMRI trial: Magnetic resonance spectroscopy imaging can define tumor areas enriched in glioblastoma stem-like cells
por: Lemarié, Anthony, et al.
Publicado: (2023)

Genome-wide CRISPR screens define determinants of epithelial-mesenchymal transition mediated immune evasion by pancreatic cancer cells
por: Gu, Yuanzhuo, et al.
Publicado: (2023)

Nonredundancy of IL-1α and IL-1β is defined by distinct regulation of tissues orchestrating resistance versus tolerance to infection
por: Eislmayr, Kevin, et al.
Publicado: (2022)

Discovering a uniform functional trade-off of the CBC-type 2,3-oxidosqualene cyclases and deciphering its chemical logic
por: Zhang, Fan, et al.
Publicado: (2023)

BMFPs, a versatile therapeutic tool for redirecting a preexisting Epstein-Barr virus antibody response toward defined target cells
por: Gamain, Benoît, et al.
Publicado: (2022)

Age-related loss of chromosome Y is associated with levels of sex hormone binding globulin and clonal hematopoiesis defined by TET2, TP53, and CBL mutations
por: Dawoud, Ahmed A. Z., et al.
Publicado: (2023)

The deubiquitinases UBP12 and UBP13 integrate with the E3 ubiquitin ligase XBAT35.2 to modulate VPS23A stability in ABA signaling
por: Liu, Guangchao, et al.
Publicado: (2022)

DIRECT-NET: An efficient method to discover cis-regulatory elements and construct regulatory networks from single-cell multiomics data
por: Zhang, Lihua, et al.
Publicado: (2022)

Improving the efficiency of Rubisco by resurrecting its ancestors in the family Solanaceae
por: Lin, Myat T., et al.
Publicado: (2022)

Desmosomal proteins of DSC2 and PKP1 promote cancer cells survival and metastasis by increasing cluster formation in circulatory system
por: Li, Koukou, et al.
Publicado: (2021)

Synthetic gene circuits for preventing disruption of the circadian clock due to interleukin-1–induced inflammation
por: Pferdehirt, Lara, et al.
Publicado: (2022)

Autophagy supports mitochondrial metabolism through the regulation of iron homeostasis in pancreatic cancer
por: Mukhopadhyay, Subhadip, et al.
Publicado: (2023)

Stem cell–homing hydrogel-based miR-29b-5p delivery promotes cartilage regeneration by suppressing senescence in an osteoarthritis rat model
por: Zhu, Jinjin, et al.
Publicado: (2022)

The ion transporter Na(+)-K(+)-ATPase enables pathological B cell survival in the kidney microenvironment of lupus nephritis
por: Chernova, Irene, et al.
Publicado: (2023)

Quantitative cross-species translators of cardiac myocyte electrophysiology: Model training, experimental validation, and applications
por: Morotti, Stefano, et al.
Publicado: (2021)

TREM-2 is a sensor and activator of T cell response in SARS-CoV-2 infection
por: Wu, Yongjian, et al.
Publicado: (2021)

Circadian disruption enhances HSF1 signaling and tumorigenesis in Kras-driven lung cancer
por: Pariollaud, Marie, et al.
Publicado: (2022)

HPIP is an essential scaffolding protein running through the EGFR-RAS-ERK pathway and drives tumorigenesis
por: Jiang, Qiwei, et al.
Publicado: (2023)

Biomineralogical signatures of breast microcalcifications
por: Kunitake, Jennie A. M. R., et al.
Publicado: (2023)

Structural characterization of human urea transporters UT-A and UT-B and their inhibition
por: Chi, Gamma, et al.
Publicado: (2023)

CAGE sequencing reveals CFTR-dependent dysregulation of type I IFN signaling in activated cystic fibrosis macrophages
por: Gillan, Jonathan L., et al.
Publicado: (2023)

ssDNA nanotubes for selective targeting of glioblastoma and delivery of doxorubicin for enhanced survival
por: Harris, Michael A., et al.
Publicado: (2021)

A localized hydrogel-mediated chemotherapy causes immunogenic cell death via activation of ceramide-mediated unfolded protein response
por: Kar, Animesh, et al.
Publicado: (2023)

Structural insights for neutralization of Omicron variants BA.1, BA.2, BA.4, and BA.5 by a broadly neutralizing SARS-CoV-2 antibody
por: Kumar, Sanjeev, et al.
Publicado: (2022)

A genome-engineered bioartificial implant for autoregulated anticytokine drug delivery
por: Choi, Yun-Rak, et al.
Publicado: (2021)

Inflammation causes remodeling of mitochondrial cytochrome c oxidase mediated by the bifunctional gene C15orf48
por: Clayton, Sally A., et al.
Publicado: (2021)

Xenogeneic skin transplantation promotes angiogenesis and tissue regeneration through activated Trem2(+) macrophages
por: Henn, Dominic, et al.
Publicado: (2021)

UFMylation of MRE11 is essential for telomere length maintenance and hematopoietic stem cell survival
por: Lee, Lara, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_i1iuop64si2dcjle2lg3hsef3s