Enhanced specificity mutations perturb allosteric signaling in CRISPR-Cas9

CRISPR-Cas9 (clustered regularly interspaced short palindromic repeat and associated Cas9 protein) is a molecular tool with transformative genome editing capabilities. At the molecular level, an intricate allosteric signaling is critical for DNA cleavage, but its role in the specificity enhancement...

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Detalles Bibliográficos
Autores principales: Nierzwicki, Lukasz, East, Kyle W, Morzan, Uriel N, Arantes, Pablo R, Batista, Victor S, Lisi, George P, Palermo, Giulia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741213/
https://www.ncbi.nlm.nih.gov/pubmed/34908530
http://dx.doi.org/10.7554/eLife.73601

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741213/
https://www.ncbi.nlm.nih.gov/pubmed/34908530
http://dx.doi.org/10.7554/eLife.73601

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