Coumarins effectively inhibit bacterial α-carbonic anhydrases

Coumarins are known to act as prodrug inhibitors of mammalian α-carbonic anhydrases (CAs, EC 4.2.1.1) but they were not yet investigated for the inhibition of bacterial α-CAs. Here we demonstrate that such enzymes from the bacterial pathogens Neisseria gonorrhoeae (NgCAα) and Vibrio cholerae (VchCAα...

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Detalles Bibliográficos
Autores principales: Giovannuzzi, Simone, Hewitt, Chad S., Nocentini, Alessio, Capasso, Clemente, Flaherty, Daniel P., Supuran, Claudiu T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741243/
https://www.ncbi.nlm.nih.gov/pubmed/34979838
http://dx.doi.org/10.1080/14756366.2021.2012174

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741243/
https://www.ncbi.nlm.nih.gov/pubmed/34979838
http://dx.doi.org/10.1080/14756366.2021.2012174

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